We recently demonstrated that MC1568 (class II HDAC inhibitor) but not tubastatin A (HDAC6 selective inhibitor) lowered elevated BP in angiotensin II‐induced hypertensive mice.11, 17 Therefore, we suggested that HDAC4 and HDAC5 may be related to the development of hypertension. The gene discussed is HDAC4; the disease is Hypertension.