CaMKII is required for angiotensin II‐mediated VSMC hypertrophy.21 Our previous study also demonstrated that CaMKIIα plays a critical role in VSMC hypertrophy and hyperplasia.11 Consistent with our results, the importance of CaMKIIα in pathological vascular diseases was shown in a study that used CaMKIIα inhibitor (KN 93) to inhibit bisphenol A‐induced hypertension.22 Among different isoforms (α, β, δ or γ) of CaMKII, we studied the role of CaMKIIα in hypertension because, only CaMKIIα responded to hypertension stimulation, such as angiotensin II. This evidence concerns the gene AGT and Hypertension.