For example in the cell cycle, miRNAs we find to be associated with T2DM progression directly regulate the expression of cyclins (CCNG1), cyclins‐dependent kinases (CDK10, CDK4, CDK6), DNA helicases (MCM10, MCM3), and transcription factors (E2F3, E2F5, FOXN3). This evidence concerns the gene E2F5 and type 2 diabetes mellitus.