PQ-induced lung fibrosis has also been reported to be seriously aggravated by inflammatory reactions; to investigate the role of Keap1/p65/Nrf2 signal pathway in regulating inflammatory reactions, real-time qPCR was used to detect inflammatory cytokine mRNA expression levels in lung tissues and ELISA was employed to detect their expressions in mice periphery blood (Fig. 6d–e). The gene discussed is KEAP1; the disease is pulmonary fibrosis.