CYP2D6 and breast cancer: We enrolled breast cancer patients with low endoxifen levels on 20 mg of TAM into our intra-patient dose-escalation study of TOR (initial dose, 40 mg; escalated dose, 120 mg), for which the contribution of CYP2D6 to its bioactivation seemed lower than that for TAM [11], to investigate the intra-patient differences in the total activity of TOR calculated by the blood concentrations of the active metabolites between the 40- and 120-mg doses.