Oncologists described 26 disease-related signs and symptoms relevant to patients with HR+/HER2- advanced breast cancer; the most frequently reported were fatigue and pain (n = 5 each, 100%), followed by neurologic symptoms (confusion, dizziness, dysarthria, headaches, seizures, trouble walking, vision disturbances, etc.)and shortness of breath (n = 4 each, 80%). The gene discussed is ERBB2; the disease is breast carcinoma.