Finally, since previous literature has shown that interesting synergistic effects may be observed when milk peptides are combined with sitagliptin (Nongonierma and Fitzgerald, 2015b), one of the main DPPIV inhibitors successfully commercialized as oral drug for the treatment of T2DM, the third objective of the study was aimed at evaluating the possible synergistic activity of the RADA16-hemp hydrogels and sitagliptin. Here, DPP4 is linked to type 2 diabetes mellitus.