AKT1 and hepatocellular carcinoma: Additionally, GSK3β, chief player of Wnt/β-catenin pathway, is controlled by RAS-MAPK and PI3 K-Akt signaling cascades, and the cross-talk between GSK3β and RAS-MAPK or PI3K/AKT/mTOR signaling pathways is implicated in the pathogenesis of HCC and pancreatic cancer [59, 60].