First, we analyzed the data of 530 patients with HNSCC (TCGA, Provisional, http://www.cbioportal.org/) and found that abnormal mRNA expression and DIAPH1, DIAPH2, and DIAPH3 mutations were frequently identified in HNSCC (Figure 1(a)). The gene discussed is DIAPH3; the disease is head and neck squamous cell carcinoma.