HMGB1 and pancreatitis: Serum HMGB1 and IL-6 significantly increased with L-arginine induction of pancreatitis (95.9 ± 21.7 vs. 18.2 ± 9.7 ng/ml, p < 0.0001; 11.66 ± 2.82 vs. 3.85 ± 0.04 nmol) (Figures 3C,D).