BMPR2 and pulmonary arterial hypertension: As noted above, another group using the cercariae model of Schistosoma-PH found that mice with heterozygosity of the TGF-β family receptor BMPR2 have a worsened PH phenotype, primarily mediated by increased liver disease and more shunting of the parasite eggs to the lungs (8): dominant negative BMPR2 mutations are a common cause of heritable human PAH.