For instance, in COPD the chemokine IL-8 (CXCL-8) and signaling through the CXCR2 receptor are thought to be involved in the disease (74) and in lupus nephritis, NET formation is thought to be regulated by engagement of the uniquely human FcγRIIA by soluble immune complexes (75). The gene discussed is CXCL8; the disease is chronic obstructive pulmonary disease.