For example, in one study in H4IIE rat hepatoma cells, Hall et al. observed that insulin induces demethylation of arginine-17 on histone H3 at promoters of PEPCK and G6Pase, which correlated with the disruption of the PEPCK and G6Pase gene transcription complex, resulting in the repression of gene transcription (96). The gene discussed is PCK2; the disease is hepatocellular carcinoma.