G6PC1 and hepatocellular carcinoma: For example, in one study in H4IIE rat hepatoma cells, Hall et al. observed that insulin induces demethylation of arginine-17 on histone H3 at promoters of PEPCK and G6Pase, which correlated with the disruption of the PEPCK and G6Pase gene transcription complex, resulting in the repression of gene transcription (96).