FGF2 and pituitary gland adenoma: Additionally, FGF-2 had significantly reduced expression levels in male and female prolactinoma patients (37), together with the study showing that FGF-2 had no regulatory effect on cell proliferation (38) and no significant modulating effect on VEGF at the transcription level in human gonadotrophic cell line HP75 (35), indicating FGF-2 might only be effective only in early stages of the development of pituitary adenoma, moreover, only in human prolactinoma.