There is a report that found TIMP-2 have higher expression in more patients of invasive prolactinomas then non-invasive ones (74), most of the aforementioned studies were performed on patients with prolactinoma or mixed patients of all secreting types, the contradicting results of TIMP-2 indicating that different types of pituitary adenoma might have distinct signaling pathways regarding to invasiveness. The gene discussed is TIMP2; the disease is pituitary gland adenoma.