IL-17 immunity has been shown to be essential for muco-cutaneous protection against Candida albicans in mice and humans (61), however its dysregulation may cause a variety of disturbances, including autoimmune diseases such as psoriasis and RA, and inflammation-associated cancers such as colorectal carcinoma (62), and blocking IL-17 activity with neutralizing antibodies has emerged as a highly effective therapy for psoriasis and psoriatic arthritis (63). The gene discussed is IL17A; the disease is psoriatic arthritis.