A recent paper published in JAMA Psychiatry in which researchers evaluated basimglurant (mGluR5 NAM) for patients with MDD with inadequate antidepressant responses in the current episode found that the primary endpoint (mean change in clinician-rated depression score from baseline to endpoint) was not met, but an antidepressant effect on patient-rated measures was found across secondary endpoints (87). This evidence concerns the gene GRM5 and major depressive disorder.