For example, Eli Lilly's mGluR2/3 agonist (LY2140023) failed to meet the primary endpoints in a phase II trial (85), and another phase III trial was stopped mainly owing to the lack of efficacy; however, JNJ-40411813 (a PAM being developed by Janssen Pharmaceutica NV Beerse, Belgium, and Addex Therapeutics, Geneva, Switzerland) has been shown to have effects on negative symptoms in patients with schizophrenia in a phase II trial (85). Here, GRM2 is linked to schizophrenia.