IGF signaling overstimulation in HCC is in part due to abnormally high expression of IGF-II by means of loss of imprinting (Poirier et al., 2003) and correlates with increased HCC cells proliferation (Bae et al., 1998) and tumor neovascularization (Lahm et al., 2002). This evidence concerns the gene IGF1 and hepatocellular carcinoma.