IGF2 and hepatocellular carcinoma: Our findings that miR-let-7a targets both IGF2BP-2 and 3, and since IGF2BP-2 and 3 are essential for IGF-II stability, we can say that miR-let-7a can target IGF-II in HCC via two mechanisms; directly through binding to its mRNA and indirectly through targeting its stabilizers; IGF2BP-2/3.