Similarly, we have previously shown that another miR-let-7 family member, namely miR-let-7i directly suppresses IGF-1R, as well as indirectly through targeting IGF2BPs in HCC (Fawzy et al., 2016), thus highlighting the crucial role played by miR-let-7 family in regulating IGF-axis members in HCC. The gene discussed is IGF1R; the disease is hepatocellular carcinoma.