Among them, IGF2BP-1 has been reported to inhibit IGF-II mRNA translation during development (Nielsen et al., 1999) while on the other hand IGF2BP-2 and -3 were previously shown to promote IGF-II mRNA translation in rhabdomyosarcoma and leukemia respectively (Liao et al., 2005; Dai et al., 2011). The gene discussed is IGF2BP1; the disease is leukemia.