DDX5 is also closely related to the progression of breast cancer (Guturi et al., 2014), non-small cell lung cancer (Wang et al., 2015; Fu et al., 2017), colorectal cancer (Zhang et al., 2018), esophageal cancer (Ma et al., 2017) by regulating the Wnt/β-catenin signaling pathways. The gene discussed is DDX5; the disease is esophageal cancer.