Among low-grade (LG) astrocytomas, the grade II gemistocytic astrocytoma (GemA) is a frequent precursor of GBM and is characterized by glial fibrillary acidic protein (GFAP) expressing cells, called gemistocytes, that show a typical angular shape with plump, glassy, eosinophilic cell body (Avninder et al., 2006), voluminous homogeneous cytoplasm, eccentric nucleus, numerous nucleoli (Krouwer et al., 1991) and long, branching processes. Here, GFAP is linked to glioblastoma.