Recent findings support the role of these genes in aging or neurodegeneration: For example, C1qa as part of the complement system mediates early synapse loss in AD, while TYROBP expression is increased in AD and simultaneously increases the expression of AD-related genes such as Cd33 in an AD mouse model, consistent with its role being a hub gene (Zhang et al., 2013; Herms and Dorostkar, 2016; Haure-Mirande et al., 2018). This evidence concerns the gene CD33 and Alzheimer disease.