GRIA1 and substance dependence: Rather, our findings show that following chronic EtOH incubation and its withdrawal there is an increase in AMPA-mediated sEPSCs and in the expression of the GluA1 AMPA subunit and mGlu5 receptors (Figure 7), in agreement with reports demonstrating the implication of AMPA and mGlu5 receptors in various models of EtOH dependence and withdrawal.