Compared to the benign PNs group, FGG and FGB were significantly higher in the malignant PNs group, while IGFALS, PLXDC1, ITIH1, APP, C16orf46, AZGP1, B4DPQ3 (protein ID), A8K0D8 (protein ID), HP, and ECM1 were of significantly lower expression in the malignant PNs group. The gene discussed is APP; the disease is paraneoplastic neurologic syndrome.