Conversely, depletion of β-catenin mRNA using small interfering RNAs (siRNAs) in human APC-deficient CRC cells SW480 and SW62018 or in STF cells producing truncated APC protein resulted in a substantial decrease in mRNA levels encoding MSX1 and MSX2 (Fig. 2C). The gene discussed is MSX2; the disease is colorectal carcinoma.