Moreover, qRT- PCR assay demonstrated that SHED-Hep-transplantation markedly reduced the enhanced expression of fulminant hepatitis-associated genes including cyclin dependent kinase inhibitor (Cdkn1a), hepatocyte growth factor (Hgf), transforming growth factor beta (Tgfb), tumor necrosis factor alpha (Tnfa), and interleukin 6 (Il-6) in the recipient rat livers28 (Supplementary Fig. S4). Here, CDKN1A is linked to Fulminant hepatitis.