The copper-overloaded LEC rats exhibited a severe hepatic failure associated with the enhanced serum levels of alanine transaminase (ALT) and aspartate aminotransferase (AST) (Fig. 3d), increased serum level of total bilirubin (Fig. 4b), and reduced serum level of ceruloplasmin (Fig. 4c). This evidence concerns the gene CP and Hepatic failure.