The siATP7B-SHED-Hep-transplantation did not improve the increased serum levels of ALT, AST, or total bilirubin, the reduced serum levels of ceruloplasmin and the enhanced expression of copper-induced fulminant hepatitis-associated genes in the fulminant LEC rats 4 weeks of the transplantation (Supplementary Figs S6 and S7). Here, CP is linked to Fulminant hepatitis.