MYO7A and autosomal dominant nonsyndromic hearing loss 11: To date, there have been more than 280 different pathogenic or likely pathogenic mutations and 380 variants of uncertain significance reported from MYO7A (https://www.ncbi.nlm.nih.gov/clinvar as of Aug 2018), which have been associated with Usher syndrome 1B46, non-syndromic autosomal recessive hearing loss (DFNB2)47, and autosomal dominant hearing loss (DFNA11)48.