LCN2 and Anxiety: This analysis shows that the increase in the number of newborn neurons observed in the DG of LCN2-null mice, after exercise, may contribute to the improvements in anxiety, at least in the NSF (p = 0.07), and in contextual retrieval at the CFC test (p = 0.06; Supplementary Table 1), similarly to what others have reported on the correlation between the number of cells in the DG and the performance during acquisition in the water maze24.