CD38 and leukemia: Considering the pivotal role of CD38/cADPR pathway in the pathogenesis of inflammatory airway disorders (e.g. asthma) through regulation of immune cells chemotaxis and inflammatory reactions in response to environmental stimuli (e.g. infectious agents, allergens)63, it could be speculated that, in resident cells of the lung, this signaling pathway may also become activated during episodes of severe leukemia known for its susceptibility to hyperinflammation (e.g. infection).