IGF1 and leukemia: Therefore, we propose that overexpression of TRPV2 shall represent a key event in the transduction of signal from IGF-1/IGF-1R/PI3K system to downstream pathways (e.g. MAPK) in order to sustain survival and proliferation of leukemic blasts, especially during episodic communication of leukemia cells with IGF-1R ligands released from the surrounding microenvironment.