Whether GEM also causes the type of stress that stimulates tumour cells to heighten their immunosuppressive environment has not been fully investigated but initial experiments have shown that there is no detectable GEM-mediated increase in surface levels of PD-L1 or release of IL-10 in the cell lines tested here and that mRNA of the aforementioned genes is also not increased (data not shown). The gene discussed is IL10; the disease is neoplasm.