Although chemotherapeutic or genotoxic stresses have been implicated in the upregulation of all of the molecules identified as being upregulated by GEM, this investigation may be the first time that a single agent has been shown to increase CD95, TRAILR2, MICA/B and ULBP2/5/6 on tumour cells. Here, TNFRSF10B is linked to neoplasm.