Indeed, the anti-apoptotic effect of TFF2 was shown in vitro in several cancer cell lines: recombinant TFF2 reduced the apoptosis of MCF-7 and T47D breast carcinoma cell lines, and the addition of anti-TFF2 hSP3 accelerated the apoptosis of LS174T and SW480 colorectal carcinoma cell lines27. This evidence concerns the gene TFF2 and colorectal carcinoma.