In contrast, here we report that USP11 regulates PTEN poly-ubiquitination and protein stability in both the cytoplasm and nucleus, and in both cancerous (as an important modifier of PTEN levels/activity in prostate cancer) and non-cancerous contexts (as a vector through which cell density controls the physiological dosage of PTEN protein). The gene discussed is PTEN; the disease is prostate carcinoma.