Notably, an immunohistochemical analysis of human prostate tumors demonstrated a statistically significant positive correlation (r = 0.385, p = 0.012) between USP11 and PTEN protein levels, as 72.9% (35 of 48) of the tumors with low USP11 expression also exhibited low PTEN expression (Fig. 5e). Here, PTEN is linked to prostate neoplasm.