In agreement with these in vitro results, USP11 but not any other known PTEN DUB (including HAUSP, USP13, and OTUD3) has been shown to be downregulated in Pten knockout mouse prostates when the incidence of PIN and the increase of cell proliferation are low43,60 (Fig. 8e), implying a key role for PTEN in the control of USP11 expression in vivo. Here, USP7 is linked to prostate intraepithelial neoplasia.