CNOT3 and anemia (phenotype): While 4- and 8-week-old Cnot3−/− livers displayed various abnormalities such as irregular hepatocyte alignment, necrosis, inflammation and anemia (Figs 1 and 3), our preliminarily studies detected milder liver pathology and appearance of Cnot3-expressing hepatocytes at later stages (12-16 weeks of age).