Figure 1d analyzed the tumor metastasis (lymph node metastasis and distant organ metastasis) rate of point mutations of p53. It was shown that the tumor metastasis rates of mutated p53 at codon 175 (38.89%), codon 248 (27.78%) and codon 273 (40.00%) were more frequent. The gene discussed is TP53; the disease is metastatic malignant neoplasm in the lymph nodes.