As shown in Fig. 6a, tumor volume was 2369.66 ± 788.70 mm3 in the Flag group, 1066.16 ± 303.35 mm3 in Flag plus IR group, 2580.77 ± 664.94 mm3 in Flag-p53 group, 859.06 ± 176.12 mm3 in Flag-p53 plus IR group, 2857.55 ± 686.17 mm3 in Flag-p53 (R273H) group, and 1658.13 ± 183.92 mm3 in Flag-p53 (R273H) plus IR group. Here, TP53 is linked to neoplasm.