As a first step to investigate the relationship between p53 mutant status and the clinicopathologic features of lung cancer patients, the statistic analysis of clinicopathologic characteristics in 78 NSCLC patients was showed the mut-p53 was both positively related to the nodes metastasis (P = 0.0267) and TNM stage (P = 0.0399) (Table 1). This evidence concerns the gene TP53 and non-small cell lung carcinoma.