In addition, the recent clinical trials, EMPA-REG OUTCOME [5], CANVAS [6] and DECLARE [7] showed that the sodium-glucose cotransporter 2 inhibitors (SGLT2i’s) empagliflozin, canagliflozin and dapagliflozin reduced either composite death from cardiovascular causes and/or hospitalization for heart failure or death from any cause in patients with T2DM. The gene discussed is SLC5A2; the disease is heart failure.