IGF2 and rhabdomyosarcoma: To verify the IGF2 dependence of such murine rhabdomyosarcoma model, we obtained a rhabdomyosarcoma cell line (RMSp53Neu-5) and we treated it in vitro with NVP-AEW541, a small molecule inhibitor of IGF1R, or with specific siRNAs (Fig. 1).