There are no coding CNVs in our control databases impacting GRIK5. Similar to DMXL2, prior evidence for an association with ASD is derived from the SSC and Autism Sequencing Consortium, where there were three de novo missense variants in the GRIK5 gene in simplex ASD probands and none in the unaffected SSC siblings [4–6]. Here, GRIK5 is linked to autism.