We found the expression of GLI1, GLI2, GLI3 and their target genes FOXM1 and BMI1 in all tested glioma cell lines, whereas the normal adult brain tissue contained only the expression of GLI2 and GLI3. Thus, our data suggest that transcription factors gli are active in gliomas, but not in a normal adult brain tissue. The gene discussed is GLI2; the disease is central nervous system cancer.