Treatment of glioma cells with the inhibitors or siRNA against GLI1, GLI2, or GLI3 caused the significant decrease in the expression of gli target genes, including GLI1, FOXM1 and BMI1. We confirmed that in high-grade gliomas, gli maintain the expression of genes, determining the stem cell state, such as OCT4 or SOX2 [58], and discovered that gli regulate the expression of TET1 dioxygenase, involved in DNA demethylation and cell reprogramming [59–61]. Here, SOX2 is linked to central nervous system cancer.