While genetic deficiency of ATX is protective against hepatic steatosis and reduces hepatic inflammation in mice, potent ATX inhibition had no effect on CCl4-induced liver fibrosis and choline-deficient amino acid-defined diet-induced liver injury in rats [40] and so it is possible that ATX does not contribute to liver dysfunction in these models. The gene discussed is ENPP2; the disease is Hepatic steatosis.