While these events may provide a reason why hsa-miR-548ac miRNA levels and CD58 mRNA levels are inversely affected by the genotype, it still remains to be elucidated which precise auxiliary factors for splicing and Drosha-mediated miRNA processing may contribute to this MS-associated eQTL and whether other SNPs play a role as well. The gene discussed is DROSHA; the disease is myeloid sarcoma.