This approach is motivated by observations that CSF1R tyrosine kinase inhibitors prevent disease progression in mouse models of Alzheimer ́s disease and amyotrophic lateral sclerosis, among others by reducing invasion of macrophages (Martinez‐Muriana et al., 2016; Olmos‐Alonso et al., 2016). The gene discussed is CSF1R; the disease is early-onset autosomal dominant Alzheimer disease.