Mutations that cause FG syndrome (p.R961W) and Lujan syndrome (p.N1007S) were found to compromise the mediator‐imposed constraint on GLI3‐dependent SHH signaling and result in increased transcript levels for multiple GLI3 target genes in lymphoblasts from patients (Zhou et al., 2012). This evidence concerns the gene GLI3 and X-linked intellectual disability with marfanoid habitus.