Previous studies have reported that the levels of apoA‐I and HDL‐C are inversely related to not only the risk of colon cancer but also the prevalence of advanced colorectal adenomas.23, 24 It was reported that every 16.6 mg/dL increase in the HDL‐C level leads to a 22% decrease in colon cancer risk, a 12% increase in non‐advanced colorectal adenoma risk and a 16% decrease in advanced colorectal adenoma risk.23 Furthermore, in this study, our results revealed the correlation between HDL‐C level and CRC patients’ prognosis after curative resection. Here, APOA1 is linked to colorectal adenoma.