NRF participated in basal repression of pro‐inflammatory cytokine IL‐1‐induced activation of IL‐8.29 NRF was a negative mediator of inducible nitric‐oxide synthase (iNOS) in human A549 and HeLa cells.8 In severe COPD patients, there existed significant reduction of NRF expression, but enhanced NF‐κB activation.30 Consistently, present study also found the renal level of NRF was obviously decreased, but the inflammatory response was increased in obese mice. Here, NOS2 is linked to chronic obstructive pulmonary disease.