Meanwhile, the obvious increase of inflammatory factors, such as IL‐1β and CRP, was also found in atrial appendage tissue of AF patients in the current study, which was supported by the previous reports.28 Some miRNAs, such as miR‐2112, 13, 14, 15 and miR‐26,16, 17 are involved in the modulation of atrial fibrosis. Here, CRP is linked to atrial fibrillation.