This network is therefore likely to provide a good representation of the key events in AD pathogenesis, and reveals four proteins with the most overall influence on the correlated expression networks, based on intra-network connectivity: syntaxin binding protein 1 (STXBP1); collapsin response-mediator protein 1 (CRMP1); actin-related protein 10 homologue (ACTR10); and amphiphysin (AMPH). The gene discussed is STXBP1; the disease is Alzheimer disease.