FOXO3 and Alzheimer disease: The observation of an altered Hippo signalling pathway in all areas of the brain studied is, to our knowledge, the first time that this pathway has been directly implicated in AD, although it has previously been shown that the human orthologue of Hippo, MST1, phosphorylates Foxo3 and that this is required for neuronal death due to presence of reactive oxygen species (ROS) or lack of neurotrophic activity32.