TREG cells express the transcription factor forkhead box-P3 (FoxP3) and are the subset of T cells that suppress the activation, proliferation and effector functions of a wide range of immune cells.17 There is evidence that due to the increased metabolic demands of the tumor microenvironment (the “Warburg effect”), tumor-infiltrating lymphocytes are directed towards the expansion of Tregs cells; glucose depletion ultimately inhibits adequate CD8+ and CD4+ T-cell control of tumor growth.18 This evidence concerns the gene CD8A and neoplasm.