APOE and diabetes mellitus: In participants with DM, more ambulatory activity was associated with having higher blood IGF-1 levels (β ± standard error (SE) = 0.22 ± 0.08, p = 0.009; Table 3, Model 2), after adjusting for age, sex, BMI, smoking, total cholesterol, triglycerides, lipid medication, and APOE4 genotype.