AML patients with t(8;21)(q22;q22.1), inv(16)(p13.1q22), t(16;16)(p13.1;q22), mutated NPM1 with wild type FLT3-ITD or low FLT3-ITD allele burden or biallelic CEBPA gene mutation are recommended to receive consolidation therapy with 2–4 cycles of intermediate dose Ara-C (IDAC), whereas allogeneic hematopoietic stem cell transplantation (Allo-HSCT) is preferred for consolidation treatment in AML without favorable cytogenetics, AML with adverse risk gene mutations or AML with wild-type NPM1 and CEBPA genes [2]. The gene discussed is NPM1; the disease is acute myeloid leukemia.