For example, gemcitabine targeting RRM2 are validated for the treatment of non-small-cell lung cancer,50 ovarian cancer,51 pancreatic cancer,52 adrenocortical cancer,53 and oral squamous cell carcinoma.54 We speculate that gemcitabine can be used to treat bladder, colon, kidney, liver and prostate cancers. Here, RRM2 is linked to familial pancreatic carcinoma.