For example, five genes (FANCI, RECQL4, TACC3, CLU, and SIK1) were reported to function in different cancers10,16–19 but they could not be identified using the Illumina 450 K array data in any of the 13 cancers; in contrast, all of them were found as triple-evidenced genes in more than six cancers using the expanded data (Table S3). Here, CLU is linked to cancer.