In particular, nine genes, TNXB, RRM2, CELSR3, SLC16A3, FANCI, MMP9, MMP11, SIK1, and TRIM59 are important in both cancer diagnosis and prognosis; note that FANCI and SIK1 would be missed on using the original Illumina 450 K data. This evidence concerns the gene RRM2 and cancer.