CYGB shows variable expression in cancers: it is down-regulated in many cancers36 but up-regulated in lung and brain metastases, and head and neck cancer.37,38 The methylation level at a LAMA4 promoter CpG was found as the seventh most important feature; previously, the aberrant methylation at the LAMA4 promoter was observed in breast carcinoma39 and low methylation was associated with poor progression-free survival.40 This evidence concerns the gene CYGB and head and neck cancer.