CAV1 and psoriasis: Additionally, Cav-1 can suppress inflammation through inhibition of endothelial NO synthase (eNOS) activity.43 Further, elimination of Cav-1 promotes the polarization of M2 macrophages in mice.44 Also, cells deficient in Cav-1 demonstrate a significantly increased uptake of S. aureus45 which is believed to be involved in psoriasis.10 This effect was connected with a negative regulation of the membrane microdomain mobility through Cav-1 which anchors these domains onto the cytoskeleton.