CAV1 and scleroderma: Cav-1 is involved in control of the cell motility through interactions with the cell cytoskeleton on the inside and with extracellular matrix (ECM) on the outside.17 Cav-1 demonstrates a negative correlation with the expression of collagen I, which is especially pronounced in scleroderma,18 keloids,19 hypertrophic scars,20 and chronologically aged skin.21 Also, Cav-1 scaffolding domain peptide was shown to demonstrate antifibrotic properties both in vitro and in vivo.22