Investigating the relation to allergen specific IgE defined by a positive or negative Phadiatop, revealed significantly higher frequency of IgG-reactivity to KRATP17-1 in AD patients with positive Phadiatop compared to HC as well as higher frequency of IgG-reactivity to S100A12 in AD patients irrespective of Phadiatop compared to HC (Fig. 5a and Additional file 1: Table S3). Here, IGHE is linked to Alzheimer disease.