The highest frequency of IgG-reactivity was found against the keratin associated protein 17-1 (KRTAP17-1) among the AD patients (32%) and up to 40% among the sAD patients (Table 2) and with significantly higher frequency compared to HC (15%) for the two subgroups of AD (Fig. 2a). Here, KRTAP17-1 is linked to Alzheimer disease.