In addition to established perioperative biomarkers, a novel set of oncological relevant systemic markers involved in Th1 immune response (CXCL10) [21]; tumor associated macrophages (CXCL12) [22]; tumor suppression (Omentin-1) [23]; pro-metastatic signaling (Galectin-3) [24]; and tumor associated inflammation (Pentraxin-3) [25] were evaluated. This evidence concerns the gene LGALS3 and neoplasm.